TIMP3 and retinopathy of prematurity: In this regard, a recent study showed that sub-retinal injection of an AAV carrying any of a variety of antiangiogenic genes including endostatin, pigment epithelium-derived factor (PEDF), and tissue inhibitor of metalloproteinases 3 (TIMP3) was able to significantly inhibit pathological neovascularization in the ROP model [190].