We performed this study to examine the cytogenetic abnormalities, gene mutational profile in 560 AML patients, and more importantly, a series of gene expression levels, such as MECOM, WT1, ERG, BAALC, and 3 new ones with potential value, GATA2, SPI1 and MEIS1, to try to address this question. The gene discussed is SPI1; the disease is acute myeloid leukemia.