The patients were classified into 3 groups: Group 1, Core Binding Factor AML (CBF-AML), which includes 89 patients, Group 2, Cytogenetic intermediate risk AML, which includes 401 patients with normal karyotype (CN-AML, 320 patients) or cytogenetic aberration without prognostic significance, and Group 3, Cytogenetic high risk patients (55 patients) group. The gene discussed is CEBPZ; the disease is acute myeloid leukemia.