In terms of molecular factors, FLT3 mutations (for both OS and DFS), biallelic CEBPA mutations (for OS), NPM1-mut/DNMT3A-wt (for OS), as well as high MECOM (both for OS and DFS) and high MEIS1 (for OS) expressions were independent prognostic factors for AML (Table 4). The gene discussed is DNMT3A; the disease is acute myeloid leukemia.