KMT2A and acute myeloid leukemia: In a recent large series of 1540 patients, clinical relevance of gene mutations was analyzed, and a new genomic classification of acute myeloid leukemia was proposed, which includes the categories of mutated chromatin, RNA-splicing genes, TP53 mutations, biallelic CEBPA mutations, MLL fusion gene, GATA2, MECOM, IDH2, and t(6;9)(p23;q34)/DEK-NUP214, with each of the subtypes presenting distinct clinical behaviors [27].