KMT2A and acute myeloid leukemia: Then, it was also identified to have a high expression level in AML with other cytogenetic abnormalities and even CN-AML, exemplified as in MLL-AF9 pediatric AML, which was associated with poor prognosis [31]; as well as in M4/5, or MLL rearrangement in another Japanese series with 130 pediatric AML patients [35].