Here, TOFA + DEXA treatment led to a marked decrease in Ifit3 and Isg15 expression in the CD4+ T cells of BWF1 mice (Fig. 5a), whereas immunosuppressive treatment including steroid resulted in significant decreases of IFIT3 expression in CD3+ T cells obtained from SLE patients (Fig. 5b). This evidence concerns the gene ISG15 and systemic lupus erythematosus.