Machado[20]demonstrated that epithelial cell adhesion molecule and EMT markers are expressed in the Ewing’s sarcoma family of tumors and strongly recommended a prospective validation of immunomarkers with prognostic significance (e.g., desmoplakin, ZO-1, CK8/18, phospho-glycogen synthase kinase beta, and Snail) in a prospective series including localized and disseminated tumors. The gene discussed is TJP1; the disease is sarcoma.