SSX2 and soft tissue sarcoma: Additionally, SS is generally characterized as a high-grade and aggressive soft tissue sarcoma that is most commonly observed in the extremities of young adults[1].Patients with SS have a poor prognosis(10-year survival rate: 10–30%)[1].Moreover, SS is associated with a specific t(x;18)(p11.2;q11.2) chromosomal translocation that generates the SYT-SSX fusion gene (involving SSX1, SSX2, orSSX4); this gene is a potent oncogene that plays a key role in the pathogenesis of SS.