In recent years, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including Gefitinib, Erlotinib, Icotinib, and Afatinib have been successfully developed and demonstrated much higher response rate and less side effect than chemotherapy in the treatment of patients with advanced NSCLC with sensitizing EGFR mutations[6–10]. Here, EGFR is linked to non-small cell lung carcinoma.