CD4 and neoplasm: There is good evidence that BCC is an immunogenic tumor [5] The intra- and peritumoral inflammatory infiltrate of the BCC microenvironment is characterized by a strong predominance of T lymphocytes, mainly CD4+ T-helper (Th) cells and CD4+/CD25+/FoxP3+ T regulatory (regs) cells, with a variable number of CD8+ T cytotoxic/suppressor (Tc) cells, Langerhans cells, natural killer (NK) cells and immature dendritic cells (DC) [6, 7, 8, 9, 10].