The IL-23/Th17-related cytokines (IL-17, IL-23, IL-22) have been shown to play a significant role in cutaneous immune-mediated inflammatory diseases, including psoriasis, allergic contact dermatitis and atopic dermatitis [12, 13, 14], but their involvement in skin carcinogenesis is controversial and poorly investigated in BCC [7, 10, 14, 15]. The gene discussed is IL23A; the disease is skin basal cell carcinoma.