CD4 and psoriasis: First, VZV triggers the activation of naive T cells and promotes the replication and release of infectious virions in all CD3+ T cells, including CD4+ and CD8+ T cells.[25] Then, VZV-infected CD4+ T cells mainly exhibit a memory T-cell phenotype and express activation markers and skin-homing proteins such as cutaneous leukocyte antigen (CLA) and C-C chemokine receptor 4.[26] Moreover, the recruitment of CD4+ T cells to the skin in patients with psoriasis has been extensively investigated.