We found that Bcl-XL ectopic expression in L. infantum promastigotes and HeLa tumor cells inhibited the percentage of hypodiploid cells following edelfosine treatment (Table 1), further supporting the critical role of mitochondria in the induction of apoptosis-like cell death in Leishmania and tumor cells treated with edelfosine. This evidence concerns the gene BCL2L1 and neoplasm.