Stimulation of plasma membrane receptors that induce PI(4,5)P2 hydrolysis via phospholipase C (PLC) activation, was shown to inhibit both heterologously expressed TRPM3 channels (Badheka et al., 2015; Tóth et al., 2015) and endogenous TRPM3 in insulinoma cells (Tóth et al., 2015). This evidence concerns the gene TRPM3 and pancreatic insulinoma.