TNFAIP3 and neoplasm: Additionally, several deubiquitination enzymes (DUBs), including A20 (also known as tumor necrosis factor α-induced protein 3; TNFAIP3) and the tumour suppressor, CYLD (also known as cylindromatosis), implicated in familial cylindromas, have been shown to control critical signalling steps upstream of the IKK complex [4,5,35].