NFKB1 and cancer: Indeed, while significant ground remains to be covered and the limited clinical successes obtained so far in select experimental clinical contexts have yet to transform into healthcare benefit for the broader patient population, the basic and translational knowledge unravelled by these studies on the biological complexity in the NF-κB pathway is providing tangible new opportunities for cancer-selective therapeutic intervention, which are certain to attract growing interest in the future and be further capitalised upon.