Interestingly, multiple chromosomal and genetic abnormalities affecting each constituent of the CBM complex or anyhow resulting in constitutive CBM complex activation have been reported in various types of lymphoma, including DLBCL and mucosa-associated lymphoid tissue (MALT) lymphoma, where they drive NF-κB activation and oncogenesis [16,17,35,64]. Here, NFKB1 is linked to lymphoma.