TNFRSF8 and cancer: Likewise, brentuximab (Vedotin, Adcetris), a toxin-conjugated chimeric antibody targeting the TNF-R-family receptor CD30 (also known as TNFRSF8), is approved for the treatment of Hodgkin’s lymphoma and anaplastic large-cell lymphoma (ALCL) (Table 1), two cancer types that express particularly high surface levels of CD30 [112].