Congruently, preclinical studies have demonstrated that the antisense oligonucleotide TLR inhibitor, IMO-8400, which specifically targets TLR7, TLR8 and TLR9, is effective in diminishing the growth of WM and DLBCL xenografts, driven by gain-of-function MYD88 mutations [118]. Here, TLR9 is linked to diffuse large B-cell lymphoma.