The GRS was built as an additive summary measure of a set of 16 genetic variants (according to the number of risk alleles for each variant) previously associated with obesity (rs9939609, FTO; rs17782313, MC4R; rs1801282, PPARG; rs1801133, MTHFR and rs894160, PLIN1) and lipid metabolism disturbances (rs1260326, GCKR; rs662799, APOA5; rs4939833, LIPG; rs1800588l, LIPC, rs328, LPL; rs12740374, CELSR2; rs429358 and rs7412, APOE; rs1799983, NOS3; rs1800777, CETP and rs1800206, PPARA). The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.