INS and type 2 diabetes mellitus: In this context, Bouchard et al. have shown that besides the inter-individual variability in the beneficial response to a PA intervention regarding cardiovascular disease (CVD) and type 2 diabetes (T2D) risk factors, some individuals may even experience negative responses, such as a decrease in plasma HDL-C or an increase in systolic blood pressure, fasting plasma insulin and plasma triglyceride (TG) levels [69].