Recent findings have also reported that the impact of gene variants within FTO gene, the first and most strongly obesity-associated gene [73,74], on obesity development is in fact attenuated by PA, i.e., the increase in BMI is 76% more pronounced in inactive individuals carrying the risk allele (Pinteraction = 0.004) [75]. Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.