INS and diabetes mellitus: The authors found that 383 CpG sites (0.08% of tested CpGs) showed significant associations after correction for multiple testing, including known diabetes loci, e.g., ADCY5, KCNJ11, HLA-DQA1, INS, PDX1, and GRB10. The CpGs of significant cis-mQTLs were over-represented in the gene body and outside of CpG islands.