RNLS and type 1 diabetes mellitus: The alleles that confer susceptibility to T1D at IL-2, IL2/4q27 (rs2,069,763) and renalase, flavin adenine dinucleotide (FAD)-dependent amine oxidase (RNLS)/10q23.31 (rs10,509,540), were associated with a lower age at diagnosis (more rapid progressors) with individuals carrying the susceptible homozygous genotype being, on average, 7 months younger at diagnosis than those carrying the protective homozygous genotypes [66].