As listed in Table 1, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that 19 biological and signal pathways were affected in UTUC tissues, while the top three pathways included MAPK (Figure S1), PI3K/Akt (Figure S2), and tight junction (TJ) pathways (Figure 3). Here, AKT1 is linked to renal pelvis/ureter urothelial carcinoma.