PVT1 and diabetic kidney disease: Downregulation of PVT1 in human mesangial cells corresponded with reduced mRNA and protein levels of fibronectin and collagen type IV α 1, and regulators of ECM proteins, TGF-β1 and plasminogen activator inhibitor [69], suggesting that this lncRNA may mediate the development and progression of diabetic kidney disease through mechanisms involving both increased synthesis and decreased degradation of specific ECM components.