H19 expression is also downregulated by hyperinsulinemia through a pathway involving phosphatidylinositide 3-kinase/protein kinase B (PI3K/AK)-dependent phosphorylation of the miRNA-processing factor KH-type regulatory splicing protein (KSRP), which promotes let-7 biogenesis and subsequent H19 destabilization. This evidence concerns the gene H19 and Hyperinsulinemia.