A CXCR4 antagonist, plerixafor, had no effects on CML progression in mice intravenously injected with BCR-ABL-transduced mouse 32D cells, but its combination with nilotinib significantly delayed time to relapse, and significantly prolonged survival when compared with nilotinib monotherapy, without any significant effects on the body weights of the mice [78]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.