CCL3 and chronic myelogenous leukemia, BCR-ABL1 positive: Collectively, basophilia, a frequently observed hematological abnormality in CML patients, may not simply be an accompanying phenomenon but may have a pathogenic role in CML development, by producing abundantly CCL3, which can dampen normal HSPC but not LSC proliferation, and eventually provide LSCs with a growth advantage over normal HSPCs, particularly at the early phase of CML development (Figure 3).