Given the essential and conserved role of tfap2α in craniofacial development (de Crozé et al., 2011; Hoffman et al., 2007; Luo et al., 2003; Martinelli et al., 2011; Meshcheryakova et al., 2015; Van Otterloo et al., 2012; Hong et al., 2014), as well as its ability to reduce the proliferation and migration of multiple cancer cells including those derived from neural crest cells (Su et al., 2014; Li et al., 2010; Bennett et al., 2009; Orso et al., 2007), it will be essential to study the potential regulation of tfap2α by human ADAM proteins. This evidence concerns the gene TFAP2A and cancer.