In this perspective, Hillman et al. [35] performed the first study (on a sample of 132 newborns), investigating high sensitivity C-Reactive Protein (CRP) levels, as marker of low grade inflammation [39], detecting significantly higher levels of this mediator in patients diagnosed for PDA [35]; successively, Meinarde et al. [40] detected the same result analyzing 88 newborns. This evidence concerns the gene CRP and Patent ductus arteriosus.