Abu-Hassan et al. (2015) developed a protocol to induce a sublethal injury with saponin to mimic a glaucomatous TM injury in an ex vivo model and were able to correct the glaucoma phenotype. We observed a modest decline in a model of inducible cytoablation mediated by an HSV-tk suicide vector (Zhang et al., 2014). This evidence concerns the gene TKT and glaucoma.