Interrogating these T2D variants in the GTEx dataset (GTEx Consortium, 2015), we uncovered a nominally significant association between SNP rs6134031 and JAG1 expression, in Esophagus–Muscularis (Beta = − 0.15, P = 0.0073, Fig. S2) and a marginal correlation in pancreatic tissue which is of potential biological relevance to T2D (Beta = −0.13, P = 0.071, Fig. S2). Here, JAG1 is linked to type 2 diabetes mellitus.