Furthermore, when the above variables, found to be significant in the univariate analysis, were introduced into the logistic model, APCHCE II score (OR, 1.171; 95% CI, 1.110–1.235; p = .002), S100B level (OR, 1.009; 95% CI, 1.007–1.012; p = .004), C‐reactive protein level (OR, 1.007; 95% CI, 1.004–1.011; p = .012), and galectin‐3 level (OR, 1.170; 95% CI, 1.116–1.226; p = .001) were identified as the independent predictors for delirium of postpartum ICU women. Here, S100B is linked to delirium.