Significant increases in NET production in response to no stimulant (9,735 AFU versus 11,347 AFU, p = 0.0209), IL-8 (8,644 AFU versus 11,915 AFU, p = 0.0032), and LPS (10,576 AFU versus 12,473 AFU, p = 0.0428) were identified in patients with colorectal cancer. Here, CXCL8 is linked to colorectal cancer.