Hausenloy et al. [12] found that IPC induced a biphasic response in Akt and Erk1/2 phosphorylation in isolated perfused rat hearts, indicating that IPC resulted in an immediate increase in Akt and Erk1/2 phosphorylation, which declined during the ischemia period followed by a second increase at reperfusion. The gene discussed is AKT1; the disease is ischemia.