In this study, regarding stromal Cav-1 expression, it was more frequently downregulated in diffuse-type (58.2%) than mixed or intestinal-type (41.8%) of Lauren classification (P = 0.045), which is consistent with the previous reports [29, 30], and stromal Cav-1 protein did not show the prognostic role in curatively resected GC. Here, CAV1 is linked to gastric cancer.