Although primary tumoral Cav-1 overexpression was documented to associate with lymph node metastasis and advanced TNM stage in the previous study [10], our results suggested that primary tumoral Cav-1 expression was not correlated with these clinicopathological features and clinical outcomes, which is in consistency with Barresi et al.'s study [29]. Here, CAV1 is linked to metastatic malignant neoplasm in the lymph nodes.