Tumor suppressive function of Cav-1 is mediated by induction of the cell cycle arrest of G0-G1-phase in fibroblasts through a p53/p21-dependent pathway [25], inhibition of Wnt/β-catenin signaling in epithelial cell [26], and activation of cell-matrix interactions toward the basal membrane [27]. Here, TP53 is linked to neoplasm.