ARHGAP35 and breast carcinoma: Goetz et al. reported that Cav-1 expression in the CAFs of breast cancer correlated with low survival and that stromal Cav-1, through p190RhoGAP regulation, favors remodels peri- and intratumoral microenvironments to facilitate tumor invasion, correlating with increased metastatic potency in vitro and in vivo [16].