CAV1 and metastatic neoplasm: However, our present study showed that metastatic tumoral Cav-1 expression was related with high LNR (P = 0.015) and perivascular invasion (P = 0.069) and that its elevated expression had a strongly negative correlation with clinical prognosis, which suggest that Cav-1 protein plays a more significant role in metastatic tumor than the primary tumor.