ERBB/HER is a family of four transmembrane receptor tyrosine kinases including epidermal HER1/ERBB1 (also named as epidermal growth factor receptor), HER2/ ERBB2, HER3/ERBB3 and HER4/ ERBB4, couples binding of extracellular growth factor ligands to intracellular signaling pathways (Arteaga and Engelman, 2014[2]), and involved in different essential endometriosis related cellular processes such as proliferation, differentiation, cell motility, migration, adhesion and survival (Figure 5(Fig. 5)) (Kanehisa Laboratories, 2016[29]). This evidence concerns the gene ERBB4 and endometriosis.