ELN and atherosclerosis: It may be due to intimal layer migration/proliferation of vascular smooth muscle cell, sub-endothelial collagen, and collagen cross-linking, elastin fragmentation, and proteoglycan function increased wherever endothelial permeability improved, endothelial nitric oxide values reduced, endothelin function increased, inflammatory markers values improved, and superoxide dismutase activity decreased with vascular stiffness and atherosclerosis process (Chow et al., 2013[7]; Wagenseil and Mecham, 2012[40]).