In their recent study, In their recent study, Bantel et al. applied an improved ELISA for serum cytokeratin-18 fragment detection suggesting the use of the method to evaluate the early stages of development of NASH; it also enables distinguishing differences between patients with a minimal (≤10%) and advanced (>10%) hepatic steatosis [26]. The gene discussed is KRT18; the disease is metabolic dysfunction-associated steatohepatitis.