The ROC analysis revealed that serum M30 CK-18 showed 75% sensitivity and 75% specificity in differentiating between mild, moderate, and severe inflammation at a concentration of >204 U/L, whereas higher concentration (>330 U/L) achieved 89% sensitivity and 78% specificity between mild and moderate to advanced liver fibrosis in chronic hepatitis C [24]. The gene discussed is KRT18; the disease is chronic hepatitis C virus infection.