IL17A and myocardial infarction: Interestingly, recent studies have proposed that the deficiency of IL-17A could ameliorate left ventricular remodeling after MI [20,21], suggesting that IL-17A is detrimental to the maintenance of cardiac homeostasis after MI; however, it is required to clarify the biological significance of RORγt-expressing cells that produce IL-17A, because IL-17A is a pleiotropic cytokine and locally functions in various tissues.