Adjusted event rates stratified by diabetes treatment were higher if sulfonylurea were combined with insulin: 6.7 events/100 patient-years (sulfonylurea + insulin), 4.9 events/100 patient-years (sulfonylurea + insulin + other OAD), 3.1 events/100 patient-years (sulfonylurea + other OAD) and 3.8 (sulfonylurea only) [54]. The gene discussed is INS; the disease is diabetes mellitus.