Analyses of time trends of antihyperglycaemic therapy and glycaemic control in 149,720 adult subjects with T2DM between 2002 and 2014 in DPV registry from Germany and Austria showed an increase in insulin therapy, particular as BOT while non-pharmacological therapy decreased [55].While risk of hypoglycemia often increases with tightening of blood glucose goals, the global HAT study showed an association between increased rates of hypoglycemia and duration of insulin therapy but no significant association with HbA1c level in T2DM [56]. The gene discussed is INS; the disease is type 2 diabetes mellitus.