Along with high amounts of Pol II and p300 binding at Amp1 of Eomes and Cd27, CD8+ T cells isolated from Zbtb32-/- mice at day 6 post-LCMV-Armstrong infection had increased amounts of H3Ac, H3K4me3 and H3K36me3, modifications that correlate with a permissive chromatin state [34], and reduced amounts of repressive H3K9me2, H3K9me3 and H3K27me3 modifications [34], compared to CD8+ T cells from WT mice (Fig 6E). This evidence concerns the gene EP300 and infection.