To understand the mechanism by which ZBTB32 regulates immune response during LCMV-Armstrong infection, we chose to assess candidates genes previously shown to regulate effector-memory CD8+ T cell differentiation and survival [2–4,33], and compared mRNA levels in WT and Zbtb32-/- P14 cells at several timepoints post-infection (Fig 6A and S5A Fig). Here, CD8A is linked to infection.