These data indicated that IL-4Rα knockdown ameliorate granulomatous inflammation, hepato- and splenomegaly and liver fibrosis during chronic schistosomiasis further consolidating the idea of a deleterious role for IL-4Rα signaling in mediating fibroproliferative pathology during chronic schistosomiasis. The gene discussed is IL4R; the disease is Hepatic fibrosis.