S. mansoni-infected mice following IL-4Rα knockdown at 16 weeks post-infection, i.e. iCre-/+IL-4Rα-/lox Tam16 mice (Fig 6A) did not result in any weight loss (Fig 6B) or mortality (Fig 6C), for up to 24 weeks post infection. The gene discussed is IL4R; the disease is infection.