Hence, the immune and histopathological response of Tam2-fed RosaCreERT2-/+IL-4Rα-/lox mice (termed iCre-/+IL-4Rα-/lox Tam2, Fig 4A), which might associate with the host premature death during experimental schistosomiasis was dissected. The gene discussed is IL4R; the disease is schistosomiasis.