However, the constitutive lack of IL-4Rα led such transgenic mice to succumb prematurely to experimental schistosomiasis with high (acute model) as well as low (chronic model) infection doses i.e. chronic model of infections succumb during the acute phase in the absence of IL-4Rα [30] casting an equivoque on the reliability of using models of constitutive deletion of IL-4Rα to assess the role of this receptor during chronic schistosomiasis. Here, IL4R is linked to infection.