As expected, from our previous mortality studies [25,27], body weights of S. mansoni-infected IL-4Rα-/- and iCre-/+IL-4Rα-/lox Tam2 mice rapidly declined starting 6 weeks post-infection (Fig 4P) that preceded the death of these animals (Fig 4Q) when compared to IL-4Rα-responsive control mice. The gene discussed is IL4R; the disease is infection.