Ex vivo stimulation and subsequent intracellular FACS analysis of MLN cells from S. mansoni-infected iCre-/+IL-4Rα-/lox Tam6 animals at week 7 post infection revealed impaired IL-4 production, similar to global IL-4Rα-/- mice (Fig 5B and 5C), whereas IFN-γ responses were similar compared to IL-4Rα-/lox and IL-4Rα+/+ control mice (Fig 5B and 5D). Here, IL4R is linked to infection.