IL4R and infection: However, the body weights of S. mansoni-infected iCre-/+IL-4Rα-/lox Tam6 mice rapidly declined following Tamoxifen-driven removal of IL-4Rα at 6 weeks post-infection similar to IL-4Rα-/- mice (Fig 5P) and culminated into the early death of these animals (Fig 5Q), when compared to IL-4Rα-responsive control mice.