Indeed, removal of IL-4Rα in Tam16-fed S. mansoni-infected RosaCreERT2-/+IL-4Rα-/lox mice failed to affect the morbidity (as indicated by serum levels of alanine transaminase as a marker of liver disease (S3 Fig) and the mortality (Fig 3B) up to 24 weeks post-infection, further supporting a dispensable role of IL-4Rα mediated signaling during chronic schistosomiasis. The gene discussed is GPT; the disease is liver disorder.