Of interest, regulatory B cell frequencies increased during infection and particularly in infected iCre-/+IL-4Rα-/lox Tam16 mice (Fig 7M and 7N) amid a rather stable total count in S. mansoni-infected iCre-/+IL-4Rα-/lox Tam16 animals when compared to littermate controls (Fig 7O). This evidence concerns the gene IL4R and infection.