Among all the cells incubated in the Myc-CCDC3 media (Supplementary Fig. 3e and f), liver cancer cells, such as Huh-7 (Fig. 4a), HepG2 and PLC-PRF-5 cells (Supplementary Fig. 3e), showed specific IF signals lined up on their cytoplasmic membrane. Here, CCDC3 is linked to liver cancer.