In the dominant genetic model analyses (Supplementary Table S1), 44 variants showed significant associations with lung cancer risk, of which seven had non-significant association in the main allelic meta-analyses yet, interestingly, two (ATM rs66467 and REV3L rs465646) showed strong and moderate cumulative epidemiological﻿ evidence, respectively (Table 2, Supplementary Table S2). The gene discussed is REV3L; the disease is lung cancer.