The results of subgroup meta-analyses by ethnicity supported the well-known cognition of “racial” differences in genetic effects for complex diseases including lung cancer41 and indicated that some variants (eg, APEX1 rs1130409, CHRNA5 rs16969968, ERCC2 rs13181, SOD2 rs4880, and CYP2E1 rs6413432) with strong evidence may be ethnic-specifically associated with lung cancer risk. The gene discussed is CYP2E1; the disease is lung carcinoma.