In the NSCLC subgroup, statistical significant associations were found for 25 variants where eight variants (CHRNA5 rs16969968, CLPTM1L rs402710, CYP2E1 rs6413432, ERCC1 rs11615, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, and TERT rs2736098) demonstrated strong cumulative epidemiological evidence (Table 3, Supplementary Table S6). The gene discussed is CHRNA5; the disease is non-small cell lung carcinoma.