ALOX15 has been shown to be linked with nonalcoholic fatty liver disease and high fat diet-induced steatohepatitis18, 19, the present study suggests that ALOX15/13-HODE signaling promoted alcohol-induced hepatic steatosis, ROS production, ER stress, alteration of lipid metabolism, and apoptosis, and knockout of ALOX15 protected mice against alcohol-induced hepatic injury. The gene discussed is ALOX15; the disease is Hepatic steatosis.