PTEN and breast cancer: In breast cancer, miR-374a was remarkably upregulated in metastatic breast cancer cells through the direct target of WIF1, Wnt5a, and PTEN, which is a key suppressor of oncogenic PI3K/Akt signaling in breast cancer, especially in TNBCs, and positively correlated to disease-free survival ratio and negatively correlated to invasive grade12, 13.