CD4 and intrahepatic cholangiocarcinoma: We found, however, a negative correlation between CD4 (R = −0.07, p < 0.05) and CD8 (R = −0.9, p = 0.02) proliferation induced by MoDCs and G-CSF plasma concentrations from patients with CIN3 lesions, and also negative correlation between CD4 (R = −0.9, p < 0.05) proliferation and G-CSF plasma concentrations from ICC patients (Fig. 7E).