While this likely indicates enhanced protease-serpin interactions in the retina in glaucoma, it could potentially also be caused by combination of several other factors such as conformational changes in neuroserpin upon oxidation36 leading to a neuroserpin-plasmin complex formation in vivo that is better recognised by the immunoprecipitating antibodies or reduced clearance of the plasmin-neuroserpin complex from the retina under glaucoma conditions. Here, SERPINI1 is linked to glaucoma.