PLAU and glaucoma: Both tPA and uPA activity plots depicted a multiphasic sigmoidal slope (dotted line) (Figs S3C and S4C) (tPA human: R2 = control 0.91; glaucoma = 0.88; uPA human: R2 = control 0.93; glaucoma = 0.90) (tPA rat: R2 = control 0.66; glaucoma = 0.67; uPA rat: R2 = control 0.60; high IOP = 0.81) with an initial log phase followed by a plateau stage.