Mechanistically, miR-584-3p interacts with Argonaute 2 (AGO2) to recruit enhancer of zeste homolog 2 (EZH2) and euchromatic histone lysine methyltransferase 2 (EHMT2), which results in enrichment of repressive epigenetic markers and decreased binding of YY1 to MMP-14 promoter, thus inhibiting the tumorigenesis and aggressiveness of gastric cancer. The gene discussed is MMP14; the disease is gastric cancer.