Notably, ectopic expression of miR-584-3p abolished the increase in expression and promoter activity of MMP-14 and enrichment of YY1 induced by transfection of YY1 in prostate cancer PC-3 cells and colon cancer LoVo cells (Supplementary Fig. S3b, Fig. S3c, and Fig. S3d), suggesting the potential roles of miR-558-3p and YY1 in regulating MMP-14 expression in these types of cancers. This evidence concerns the gene YY1 and malignant colon neoplasm.