Over-expression of miR-584-3p increased the levels of histone H3 lysine 27 trimethylation (H3K27me3) and histone H3 lysine 9 dimethylation (H3K9me2), which were abolished by knockdown of AGO2 or treatment with established specific inhibitors of EZH2 and EHMT2, GSK34325 and A-36626, in gastric cancer cells (Supplementary Fig. S2e). Here, AGO2 is linked to gastric cancer.