In multivariate analysis CG genotype for 174 G/C of IL-6 (odds ratio OR = 7.5; 95% CI: 1.1–50; p = 0.03), allele A in C-1260A of CYP27B1 (OR = 4.3; 95%CI: 1.3–13.8; p = 0.01), lower GFR (MDRD) (OR = 0.96; 95%CI: 0.92–1.0; p = 0.05), higher level of cystatin C (OR = 6.6; 95%CI: 1.2–35.2; p = 0.02) and lower level of TGF beta 1 (OR = 0.96; 95%CI: 0.57–0.84; p = 0.001) were independent risk factors of worse course of HF (Table 5). This evidence concerns the gene CST3 and hydrops fetalis.