For FTD-ALS, 60 out of 224 genes could be validated in total (Fig. 5, Table S5) from which 5 genes were seen across two validation sets; CCND2, PCNX, PTP4A2, METTL7A, and PALLD. To further specify potential candidate genes that are implicated in FTD-ALS, we only included genes with aberrant DNA-methylation and deleterious SNPs, and detected 9 genes (Table 1, and Fig. 5). This evidence concerns the gene PALLD and frontotemporal dementia.