Evaluation of nuclear versus cytoplasmic YAP1 in primary and metastatic tumor nodules receiving platelet transfusions or vehicle treatment revealed an up to 2.3-fold increase in the number of nuclear YAP1-positive cells in metastatic nodules in mice with thrombocytosis (Fig. 5h) compared to primary tumors and metastatic nodules from mice without thrombocytosis, further supporting the role of YAP1 in metastatic spread of ovarian cancer. Here, YAP1 is linked to thrombocytosis disease.