E2F1 and cancer: Gene Set Enrichment Analysis (GSEA) revealed that pathways related to cell cycle and E2F1-signaling were the most upregulated pathways (Fig. 2d and Supplementary Fig. 2b), whereas genes related to hypoxia, oxidative phosphorylation and p53 were downregulated in cancer cells upon platelet incubation (Supplementary Fig. 2c, d).