YAP1 and thrombocytosis disease: Importantly, this effect of thrombocytosis on the number and total weight of metastatic nodules was completely abolished by simultaneous depletion of YAP1. Moreover, primary tumor weight, number of nodules and aggregate total tumor weight in the control and both YAP1 siRNA-DOPC groups were comparable, irrespective of platelet transfusions (Fig. 5c, d and Supplementary Fig. 5b).