In the present study, we therefore investigated the role of CK7 and CK20 expressions with clinical parameters and prognostic outcomes of lung cancer, so as to explore the association between CK7/CK20 and lung cancer, and to study the influence of various clinical parameters on the prognosis of lung cancer patients, thus making a meaningful exploration for lung cancer diagnosis, treatment, and prognosis. This evidence concerns the gene KRT20 and lung cancer.