CB1R has been implicated in the pathology of different liver diseases with various etiologies including NAFLD (Osei‐Hyiaman et al, 2008), AFLD (Jeong et al, 2008), viral hepatitis (Hezode et al, 2005), liver fibrosis (Teixeira‐Clerc et al, 2006), cirrhosis (Giannone et al, 2012), and liver cancer (Mukhopadhyay et al, 2015). This evidence concerns the gene CNR1 and Hepatic fibrosis.