A potential unifying factor upstream of these genes is the cannabinoid‐1 receptor, stimulation of which was found to upregulate several of the above‐listed target proteins, including Fasn, Pklr, Pnpla3, and Pcsk9 in mouse models of obesity/metabolic syndrome and HCC, as documented and detailed. The gene discussed is PKLR; the disease is obesity due to melanocortin 4 receptor deficiency.