KDM5C is involved in neuronal development [17], and KDM5D, which is encoded by a Y-chromosome-encoded (male specific) gene, has a role in spermatogenesis [18], Consequently, KDM5 members are current medicinal chemistry targets for cancer, with KDM5B being a particular focus due to its role in tumor maintenance and progression [13]. The gene discussed is KDM5B; the disease is cancer.