Because signal transducer and activator of transcription 3 (STAT3) and dedicator of cytokinesis 8 (DOCK8) are also reported as candidates for HIES (Engelhardt et al., 2009, Minegishi et al., 2007), these factors may possibly contribute to the elevated IgE in T1D patients. Here, IGHE is linked to type 1 diabetes mellitus.