TYK2 and type 1 diabetes mellitus: Although we assessed the association of IgE levels and TYK2 promoter genotype in T1D patients, we found no difference in IgE levels between TYK2 promoter variant and wild type genotype (wild, median, 58.3 U/ml; variant, median, 45.8; p = 0.440) (Fig. S1).