IGHE and type 1 diabetes mellitus: Consequently, T1D patients showed higher IgE levels (median, 56.7 U/ml; p < 0.0001) than T2D patients (median, 22.5 U/ml) or YH (median, 43.3 U/ml) (Fig. 1), suggesting that elevated IgE in T1D patients have distinct clinical significance.