AR and posterior cortical atrophy: Using the HALLMARK function from GSEA we established that most of those genes lost in response to Bag-1L KO are associated with ‘androgen response’ (p=3.39×10−31; q = 1.7×10−29) (Figure 1—figure supplement 3), supporting our hypothesis that one of the functions of Bag-1L in PCa is to regulate AR transactivation.