TRIM63 and heart failure: Murf1 expression is elevated under muscle catabolic conditions and overexpression of murf1 in the heart results in a thin ventricular wall and a rapid transition to heart failure upon transaortic constriction, suggesting that MuRF1 is a major player in muscle catabolic processes (Bodine et al., 2001; Labeit et al., 2010; Baehr et al., 2011; Files et al., 2012; Gomes et al., 2012; Bodine and Baehr, 2014).