However, in a study by Garcia-Marin et al., it was observed that there was a complete absence of GAT1 and vGAT-positive processes surrounding the soma of pyramidal cells in regions that were in contact with Aβ plaques, in both the AD human cortex (multiple regions) and in that of APP/PS1 (12-month-old) transgenic mice (multiple regions), while pyramidal cells which did not contact plaques exhibited perisomatic GAT1/vGAT labeling [225]. This evidence concerns the gene PSEN1 and Alzheimer disease.