AKT1 and cancer: The pro-oxidant activities of polyphenols in cancer cells generates ROS, producing [49,59,60] (1) cell cycle arrest [61]; (2) induction of apoptosis and DNA fragmentation [62]; (3) inhibition of proliferation signaling pathways, including epidermal growth factor receptor/mitogen activated protein kinase (EGFR/MAPK), phosphatidylinositide 3-kinases/protein kinase B (PI3K/Akt) [63], and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB) [64] and (4) anti-inflammatory effects [65,66].