Another study demonstrated that 10 μM of a mixture of isoflavones (70.5% genistein, 26.3% diadzein, 0.3% glycitein) resulted in the significant upregulation of miRNA 200 and miRNA let-7, as well as significant upregulation of E-cadherin and downregulation of mesenchymal markers, including vemintin, ZEB1 and slug in gemcitabine-resistant pancreatic cancer cells [203]. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.