However, it is important to note that Nrf2 induction does not necessarily boost cell proliferation—particularly in early-stage tumour cells—and has in fact been reported to repress the proliferation of lung-cancer cells by inducing the breakdown of polyamines [37], whilst even to be responsible for the anti-proliferative effects of allicin in HCT-116 cells [38]. Here, NFE2L2 is linked to neoplasm.