Most of the recent papers dealing with the Humanin peptide have centred on its ability to act as a protective agent, especially in AD (Hashimoto et al., 2001), a retrograde signal peptide (Lee et al., 2013), or as an agent improving cognition (Murakami et al., 2017; Wu et al., 2017), but little has been said about the underlying biology of the Humanin gene. The gene discussed is MT-RNR2; the disease is Alzheimer disease.